A psilocybin-containing mushroom has an interesting history. A lot of Mesoamerican cultures pre-Columbian ate psilocybin mushroom spores for sale mushrooms in rituals and ceremonies. Research suggests that these religious practices were practiced for more than three thousand years and spanned across the Valley of Mexico to Central America. While the cultures of these times consumed the fungi for their spiritual benefits, some were also educated and awe-inspiring in their thinking.

Numerous studies have demonstrated that water extracts of P. cubensis as well as Pan cyanescens mushrooms are cardioprotective. Their antioxidant properties are mediated by beta-adrenergic receptor1. Flavonoids are another mycochemical compound that is found in mushrooms and provide anti-inflammatory and anti-carcinogenic effects.

Two extracts of mushrooms were shown to reduce the ET-1-induced hypertrophy of cardiomyocytes. These extracts inhibited ET-1-induced TNF-a which is a pro-inflammatory cell cytokine. Both of the mushrooms have been found to be effective in the treatment of heart failure. However, there are significant negative side effects that could be due to the use of these mushrooms. The benefits of mushroom extracts may outweigh any possible side effect.

These mushrooms are often consumed to experience hallucinogenic effects but they can also trigger a range of other adverse effects. While the majority of these adverse symptoms are self-limiting and minor an individual 15-year-old man experienced symptoms of acute kidney injury 36 hours after eating Psilocybe cubensis mushrooms. He was reported to have purchased an "grow kit" for these mushrooms and shared the harvested harvest with three of his friends. In just six hours, the effects of the mushrooms on the hallucinatory system disappeared.

Intoxication by magic mushrooms is very uncommon and is usually a side effect when combined with other drugs. However, it is important to note that psilocybin-containing mushrooms may increase the heart rate and blood pressure temporarily. This may be a significant danger for people suffering from heart failure or cardiovascular illnesses. Also, people suffering from heart problems should be cautious before using psilocybe cubensis mushrooms.

Psilocin and Psilocin could be legal in many countries, however they are legal in certain states. The United States, Canada, and Brazil are only a few areas where this substance is not legal.